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(Best Syndication) Pennsylvania researchers have discovered a key regulator protein called Bcl-3 which helps the body control the inflammation response to infections. The protein does this by interfering with a critical biochemical process called ubiquitination. Previous studies found that Bcl-3 plays a role in immunity, but this is the first research to suggest it regulates inflammation by blocking ubiquitination.
Diabetes, sepsis, and rheumatoid arthritis could be treated in the future by gene therapy. “The novelty of our study is the discovery that Bcl-3 acting on gene expression has a profound effect on inflammation,” according to Ruaidhri Carmody, PhD, Senior Research Investigator in the Department of Pathology and Laboratory Medicine and first author of the Science paper.
Original post by Jeffrey Workman
